1. Eosu Kim, Jeonghun Ku, Young-Chul Jung, Hyeongrae Lee, SunI.Kim, Jae-Jin Kim, Kee Nam Koong, Dong-Ho Song, Restoration of mammilothalamic functional connectivity through thiamine replacement therapy in Wernicke's encephalopathy, Neuroscience,(in press)
6. Eosu Kim, Jeonghun Ku, Kee Namkoong, Wonho Lee, Kang Soo Lee, Ji-Yeon Park, Su Young Lee, Jae-Jin Kim, Sun I. Kim, Young-Chul Jung, Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy, Brain, 132,2, 369-376, 2008.11
There is still debate over the neural mechanisms underlying pathogenic and even recovery processes of Wernicke’s encephalopathy.Therefore, we attempted to validate the usefulness of resting-state functional connectivity analysis in assessing memory function and its neural correlation with the mammillothalamic tract in patients recovering from Wernicke’s encephalopathy. Seven chronic alcoholics recovering from Wernicke’s encephalopathy, 14 alcoholic comparisons without Wernicke’s encephalopathy, and 14 healthy comparisons underwent functional connectivity MRI scans, as well as verbal and non-verbal memory tests after at least a 1month abstinence from alcohol. Resting-state functional connectivity strength between the anterior thalamus and the mammillary bodies was investigated by calculating temporal correlations in magnetic resonance signal levels between the two regions during a 5-min passive viewing task.The mean values of the functional connectivity strength between the left anterior thalamus and the psilateralmammillary body differed significantly between Wernicke’s encephalopathy patients and healthy comparisons (P= 0.014).This connectivity strength in alcoholic comparisons fell between those of the former two groups, with a significant difference from that of healthy comparisons (P= 0.038). In addition, the strength of this left-sided functional connectivity significantly correlated with delayed verbal recall scores (r=0.771, P= 0.042) and verbal recognition score (r=0.825, P=0.022) in patients with Wernicke’s encephalopathy. Our findings indicate that memory function in patients recovering from Wernicke’s encephalopathy parallels the level of the mammillothalamic functional connectivity; this supports the usefulness of resting-state functional connectivity analysis as a practical alternative to pathological examination of the mammillothalamic tract in living patients withWernicke’s encephalopathy.
5. Kiwan Han, Jeonghun Ku∗, Kwanguk Kim, Hee Jeong Jang, Junyoung Park, Jae-Jin Kim, Chan Hyung Kim, Min-Hyung Choi, In Young Kim, Sun I. Kim, Virtual Reality Prototype for Measurement of Expression Characteristics in Emotional Situations, Computers in Biology and Medicine, 39, 173-179, 2008.12.8
4. Jeonghun Ku, Jae-Jin Kim, Young Chul Jung, Il Ho Park, Hyeongrae Lee, Kiwan Han, Kang Jun Yoon, In Young Kim, and Sun I. Kim, Brain mechanisms involved in processing unreal perceptions, NeuroImage, 43, 793–800, 2008.8
3. Sangwoo Cho, Jeonghun Ku, Jinsick Park, Kiwan Han, Hyeongrae Lee, You Kyong Choi, Young-Chul Jung, Kee Namkoong, Jae-jin Kim, In Young Kim, Sun I. Kim & Dong Fan Shen, Development and Verification of an Alcohol Craving Induction-Tool using Virtual Reality: Craving Characteristics in Social Pressure Situation, CyberPsychology & Behavior 11(3), p302-309, 2008.06
2. Youn Joo Kang, Jeonghun Ku, Kiwan Han, Sun I. Kim, Tae Won Yu, Jang Han Lee, Chang Il Park,Development and Clinical Trial of Virtual Reality-Based Cognitive Assessment in Patients with Stroke - Preliminary Study –CyberPsychology & Behavior 11(3), p329-339, 2008.06
1. Sun I. Kim, Jeonghun Ku, Kiwan Han, Hyeongrae Lee, Jinsick Park, Jae-Jin Kim and In Young Kim, Virtual Reality applications for Patients with schizophrenia, Journal of CyberTherapy & Rehabilitation, 1(1), P.101-112,2008.02